Industry information

Global raw material industry dynamics in 2025: new trends in the health care products, cosmetics and feed raw materials markets

1. Health food raw materials: Synthetic biology promotes the technological revolution of "green bird's nest"

In the first quarter of 2025, Singapore biotechnology company SynBioHealth announced that it had successfully mass-produced synthetic bird's nest active ingredients (bird's nest acid, EGF) through cell culture technology. Its cost was 60% lower than that of traditional bird's nest extraction, and there was no animal harm in the production process. This breakthrough caused a shock in the global health care product raw material market. Many companies in China and Southeast Asia have signed cooperation agreements with it, and it is expected that related products will be put on the market on a large scale in 2026.

In addition, the EU recently updated the "Novel Food Ingredients Regulation" and clearly included "functional ingredients derived from cell culture" in the regulatory framework, opening up a compliance path for synthetic biology-derived health care product raw materials (such as artificial collagen and peptides). Industry analysts predict that by 2027, the global synthetic biology raw material market will exceed US$32 billion, with a compound annual growth rate of 18%.

2. Cosmetic raw materials: natural plant extracts and “zero-carbon cosmetics” become mainstream

In April 2025, the international cosmetics giant L'Oréal Group and Brazilian bio-enterprise Amazônia Green jointly launched the first "zero deforestation certified" Amazon berry extract (rich in antioxidant ingredients), and promised to achieve carbon neutrality for the entire raw material supply chain by 2030. This move has driven a surge in demand for natural plant extracts. According to Innova Market Insights data, global natural cosmetic raw material procurement volume increased by 27% year-on-year in 2025, among which aloe vera, Centella asiatica, Moringa seeds and other ingredients were the most popular.

At the same time, the European Union officially implemented the "Cosmetics Sustainable Labeling Law", requiring all imported cosmetics to label the raw material carbon footprint and biodegradability rating. Many Chinese raw material suppliers have accelerated the upgrading of environmental protection processes. For example, the "supercritical CO2 extraction technology" developed by a Shandong company can reduce the energy consumption of plant extraction by 40%, and has passed the EU ECOCERT certification.

3. Feed ingredients: Insect protein has been approved by many countries, and the process of replacing soybean meal is accelerating

In March 2025, the Food and Agriculture Organization (FAO) released a report stating that the large-scale breeding of insect proteins such as black soldier flies and mealworms has met the needs of industrial feed production, with a protein content of over 60% and carbon emissions of only 1/10 of soybean cultivation. As of this month, 15 countries and regions including China, the United States, and the European Union have approved insect protein as a raw material for poultry and aquatic feed, driving global insect protein trade to grow by 210% year-on-year.

On the other hand, affected by the dry climate in South America, soybean meal prices continued to fluctuate in 2025, prompting feed companies to accelerate the search for alternatives. The Dutch company Protix announced that it would invest in the world's largest insect protein production base in Indonesia, with an annual production capacity of 500,000 tons, mainly for the Southeast Asian aquaculture market.

4. International trade policy: RCEP member countries reach agreement on mutual recognition of raw materials

In April 2025, the member countries of the Regional Comprehensive Economic Partnership (RCEP) adopted the "Action Plan for Mutual Recognition of Cross-Border Raw Materials Quality", which established unified testing standards for more than 1,000 raw materials in the fields of health products, cosmetics and feed, and simplified the customs inspection process. This move is expected to reduce the cost of raw material trade in the Asia-Pacific region by 12%-15%, especially beneficial to the export of special categories such as Chinese herbal extracts and marine bioactive ingredients.

Outlook: Technology, environmental protection and globalization drive the future of the industry In the next three years, the raw material industry will show three major trends:

Technology integration: AI-driven ingredient screening and synthetic biological manufacturing technology further shorten the R&D cycle;

Green transformation: Carbon tariff policies force companies to optimize production processes, and bio-based packaging and recycling technologies become the key to competition;

Market differentiation: Developed countries focus on high value-added functional raw materials, and emerging markets tend to cost-effective commodities.

Conclusion

As an important participant in the global raw material supply chain, our company will continue to track policy and technology frontiers, provide customers with compliant, innovative and sustainable raw material solutions, and help seize industry opportunities.

About us

Joyous is an international supplier of health food raw materials, cosmetic raw materials and feed raw materials, committed to connecting global high-quality resources and promoting sustainable development of the industry. Follow us to get more industry insights and trade information!

Global health supplement raw materials industry trends in 2025: green technology, policy upgrades and the rise of emerging markets

New EU regulations come into effect, raising the export threshold for plant extracts.

In March 2025, the European Union officially implemented the Natural Health Ingredients Regulation (NHCR), requiring imported plant extract raw materials to provide full-chain traceability data and carbon footprint certification. The new regulations have a significant impact on popular raw materials such as curcumin and Ganoderma lucidum spore powder. Companies in major exporting countries such as China and India are accelerating the upgrade of digital production systems. Industry experts predict that the price of organic certified raw materials that meet EU standards may rise by 15%-20%, promoting the transformation of the global supply chain towards transparency and low carbonization.

Synthetic biology breakthrough: US company launches first "cell-cultured collagen peptide"

California biotech company Synthagen announced in April that its high-purity collagen peptides mass-produced through microbial fermentation technology have passed FDA-GRAS certification, and the production cost is 40% lower than that of traditional animal-derived extraction. This technology can accurately control the molecular weight (1,000-3,000 Da) to meet the needs of multiple scenarios such as beauty and joint health, which may have an impact on the traditional fish collagen market. Industry analysts pointed out that the market share of synthetic biological raw materials is expected to exceed US$18 billion in 2025, with an annual growth rate of 27%.

Southeast Asian market demand surges, probiotic raw material imports hit record highs

According to the latest report of the Asia-Pacific Journal of Nutrition, the market size of functional foods in Southeast Asia will increase by 32% year-on-year in 2024, with the import volume of probiotic raw materials in Indonesia and Vietnam increasing by 58% and 41% respectively. Local companies prefer customized strains (such as thermostable Lactobacillus plantarum LP-28) for the development of ready-to-drink beverages and snacks. Chinese suppliers occupy more than 60% of the market share in the region with their cost-effective freeze-dried powder technology.

China releases "Medicine and Food 2.0" catalogue, raw materials such as Poria cocos and mulberry leaves welcome policy dividends

In January 2025, the National Health Commission of China added 12 substances to the catalog of medicine and food, including traditional Chinese medicines Poria cocos and mulberry leaves and new resource food Haematococcus pluvialis. After the policy was relaxed, domestic companies accelerated the development of "snack-like" health products, such as instant mulberry leaf enzyme tablets and Poria cocos instant drinks. According to data from Alibaba International Station, the number of inquiries for related raw materials increased by 90% compared with the same period last year, with North American buyers taking the lead.

Sustainable procurement becomes the focus, global giants jointly launch the "Raw Materials Ethics Initiative"

Nestlé, DSM and other multinational companies jointly established the Ethical Raw Materials Alliance (ERA), requiring members to achieve 100% zero-deforestation procurement of raw materials by 2030 and protect the rights and interests of communities in origin. The production areas of Brazilian acerola cherry and Indian moringa leaves have launched farmer cooperative certification programs, and it is expected that the premium space for compliant raw materials will reach 8%-12% in 2025, promoting the comprehensive upgrade of the industry's ESG standards.

Industry Outlook

In 2025, the global health care raw material industry will continue to develop towards technology-driven, policy-compliant and sustainable development. Raw materials with clear functionality and clinical data support (such as postbiotics, specific structure hyaluronic acid) and convenient dosage forms (freeze-dried particles, nano-encapsulated powders) that adapt to cross-border e-commerce channels may become the core competition track.

About Us

Joyous company has been engaged in the foreign trade of health care raw materials for 15 years, providing one-stop procurement solutions for natural extracts, probiotics and synthetic biological raw materials certified by EU/USP standards. Keeping up with global policy trends, we help customers seize market opportunities!

Keywords: 2025 health care raw material trends, EU NHCR regulations, synthetic biological collagen, Southeast Asian probiotics market, medicine and food 2.0

Media Contact:

[Contact Name]: Julie

Tel: +86-152-931-22560 

Email:  Julie@joyouspellets.com 

Official Website: joyousbio.com

The global functional food raw materials market is experiencing explosive growth, with natural plant extracts and precision nutrition technologies leading the new trend in 2025

In the first quarter of 2025, the global health care products and functional food raw materials industry ushered in a new round of technological innovation and market demand upgrade. Natural plant active ingredients, personalized nutrition solutions and green supply chain became the three core keywords of the industry, driving the global trade scale to grow by 23% year-on-year.

1. The demand for natural plant extracts has surged, and South American and Southeast Asian raw material production areas have attracted attention. 

According to the latest report of the International Health Food Association (IHFA), the global plant-based functional raw material market is expected to exceed US$50 billion in 2025, among which adaptogens and rare berry extracts (such as Camu camu and maqui berry) have become the main growth drivers. The export volume of organic maca and acerola cherry raw materials in Peru, Brazil and other South American countries increased by 40% year-on-year. Southeast Asia has promoted the production capacity of raw materials such as moringa leaves and vanillin to the forefront of the world with its climate advantages.

Industry trends: The European Union recently updated the "List of New Food Ingredients", adding 5 plant extracts such as "Amazon Rainforest Golden Fruit (Açaí Bowl)", providing compliance guidance for related raw material export companies.

2. Precision nutrition technology has been implemented, and microencapsulated raw materials have become the focus of innovation

As consumers' demand for personalized health management has been upgraded, the application of microencapsulation technology and nanoemulsification technology in the field of raw materials has accelerated. In March 2025, a US biotechnology company announced the development of "targeted intestinal release probiotic microcapsules", which can greatly increase the survival rate of bacterial flora to 98%. At present, it has reached cooperation intentions with many Chinese OEM factories.

Foreign trade opportunities: The import demand for vitamin D3 and Omega-3 microencapsulated products in the Middle East and North Africa has surged. Customs data showed that its purchase volume in Q1 2025 increased by 67% year-on-year.

3. Carbon neutrality certification forces supply chain upgrades, and Chinese companies seize the opportunity 

As global ESG policies become stricter, raw material suppliers with "zero carbon certification" have become the core consideration of international buyers. At the beginning of 2025, many spirulina and dendrobium production bases in Yunnan, China passed the Carbon Trust certification, relying on photovoltaic agriculture and biodegradable packaging technology to double the export orders to Europe.

Policy direction: The US FDA plans to implement the "Raw Material Traceability Digitalization Act" in the second half of 2025, requiring all imported functional ingredients to provide blockchain traceability information. It is recommended that companies deploy digital compliance systems in advance.

4. Outlook for international exhibitions and industry summits 

May 2025: Germany's Vitafoods Europe will set up an "Asia-Pacific Natural Raw Materials Zone" to focus on popular categories such as Ganoderma lucidum spore oil and marine collagen peptides.  

June 2025: The Shanghai International Health and Nutrition Exhibition (NHNE) will release the "2025 Global Precision Nutrition White Paper" to analyze the trend of customized raw material production.

Conclusion

Faced with the rapid iteration of market demand and technological changes, companies need to pay close attention to policy compliance, technological innovation and sustainable supply chain construction. As a high-quality supplier of functional food ingredients worldwide,Joyous will continue to provide high-value-added natural ingredient solutions to help customers seize new heights in the global health industry.

Contact us 

For the latest raw material compliance guidelines or customized procurement solutions, please visit the official website or send an email to Julie@Joyouspellets.com.

Keywords attached: functional food ingredients, plant extracts, precision nutrition, carbon neutrality certification, 2025 industry trends.

Global health supplement raw materials industry dynamics in 2025: Synthetic biology explosion, precision nutrition deepening, EU new regulations attract attention

1. Synthetic biology reshapes the raw material supply chain, and the export of fermented ingredients surges

According to the February 2025 report of the International Nutritional Sciences Association (INSA), the global market size of health care raw materials produced by synthetic biology has exceeded US$18 billion, with an annual growth rate of 32%. Chinese companies dominate the production of astaxanthin and NMN (β-nicotinamide mononucleotide) by microbial fermentation, with exports increasing by 47% year-on-year in 2024. 

Industry case: A biotechnology company in Zhejiang announced this month that it has built the world's first "AI-regulated fermentation production line", which can increase the fermentation efficiency of collagen peptides by 300% and reduce costs by 40%. It has now obtained the EU Novel Food certification and is expected to export to Europe in 2025. Orders exceed 20,000 tons.

2. Personalized nutritional needs force raw materials to upgrade, and functional testing services become a new outlet

With the popularization of home health monitoring equipment (such as saliva RNA detectors and intestinal flora scanners), consumers' demand for "precision-matched" health care raw materials has surged. From January to March 2025, the number of inquiries for raw materials that support personalized customization (such as modular probiotic strains and variable-dose vitamin microspheres) increased by 68% year-on-year. 

Policy dynamics: The U.S. FDA issued the "Draft Guidelines for Genotype-matched Dietary Ingredients" on March 15, requiring raw material suppliers to provide SNP (single nucleotide polymorphism) compatibility data, and Chinese manufacturers need to lay out the testing and certification system in advance.

3. EU Green Traceability Act takes effect, plant raw material suppliers face compliance challenges 

EU Regulation 2024/783, which will be implemented on January 1, 2025, requires all imported plant-derived raw materials (such as ashwagandha, curcumin, etc.) to provide:

Full life cycle carbon footprint tracking (from planting to export)

Biodiversity impact assessment report 

Blockchain traceability QR code

According to customs data, China's exports of plant raw materials to Europe fell 15% year-on-year in the first quarter of 2025, but the order volume of companies with certifications such as ECOCERT grew 210% against the trend.

4. The Middle East-Southeast Asia market exploded, and the demand for halal-certified raw materials surged.

In March 2025, the Saudi Public Health Authority announced that it would invest $5 billion to subsidize the national nutrition supplement program, driving the Middle East's imports of halal-certified raw materials (such as camel milk peptides and date polyphenols) to grow by 55% year-on-year. At the same time, Indonesia promulgated the Traditional Herbal Medicine Modernization Act, requiring local companies to purchase plant extracts that have been dual-certified by GMP+Halal. Chinese suppliers can focus on categories such as myristic acid and Tongkat Ali extracts.

5. Industry event preview

April 10-12, 2025, the Singapore International Nutrition Ingredients Exhibition (Vitafoods Asia) will set up a "Synthetic Biology and Future Food" zone

May 8, 2025, the General Administration of Customs of China held an "Online Seminar on the Compliance of Import and Export of Health Ingredients" (free registration code: HZ2025ING)

Media Contact:

[Contact Name]: Julie

Tel: +86-152-931-22560 

Email:  Julie@joyouspellets.com 

Official Website: joyousbio.com

Three major trends in the global health care raw material industry in 2025: AI-driven raw material screening, new EU regulations forcing green supply chains, and the explosion of marine bioactive substances

Synthetic biology accelerates industrialization, and the EU Natural Raw Materials Traceability Act may reshape the global procurement landscape

March 26, 2025 - According to the World Health Organization's "2025 Global Dietary Supplement White Paper", the health supplement raw material market is undergoing structural changes, the penetration rate of AI technology has surged by 170% compared to 2022, and the development of marine raw materials has surpassed plant extracts for the first time. The following are the key developments in the industry in the near future:

Trend 1: AI+CRISPR technology gives birth to "super raw materials"

 • Gene editing breakthrough: BioNexus Labs in the United States announced that it has successfully cultivated genetically modified oats with a β-glucan content of 18.7% (traditional varieties only have 4%-7%) through AI prediction models and CRISPR technology, and has obtained commercialization permission from the US Department of Agriculture.

• Dynamic pricing system: The Dutch raw material trading platform PhytoChain introduced blockchain + AI algorithms, which can analyze changes in pharmacopoeia regulations in 30 countries around the world in real time, warn of supply chain risks, and help customers avoid more than US$23 million in compliance losses during the test period.

Trend 2: New EU regulations trigger a "green earthquake" in the supply chain

The EU Natural Raw Materials Traceability Act, which came into effect in January 2025, requires:

✓ All plant raw materials must provide satellite positioning planting coordinates

✓ Heavy metal detection standards are tightened to 1/3 of the original limit

✓ Carbon footprint labels are mandatory to cover the entire transportation chain Industry impact:

• China's Yunnan Panax notoginseng production area has built the world's first "digital Chinese medicine blockchain platform", realizing full-cycle traceability from planting to export, and the procurement volume of EU ETP-certified companies increased by 47% month-on-month.

• The cost of organic certification in the United States has risen by 35%, and small and medium-sized suppliers are accelerating the transfer of production capacity to Southeast Asia.

Trend 3: Deep-sea raw material development enters the "hundred-billion-dollar track"

• Antarctic krill oil 2.0: Aker BioMarine of Norway has launched phospholipid-type Omega-3 extracted by enzymatic hydrolysis technology, which has a bioavailability 200% higher than that of traditional TG/EE forms. It has reached an exclusive supply agreement of US$230 million with Nestlé Health Science.

• New discovery of marine microorganisms: The Qingdao Institute of Oceanology of the Chinese Academy of Sciences has isolated a new anti-inflammatory peptide "Maripeptide-7" from microorganisms in the Mariana Trench. Animal experiments show that its inhibition rate on intestinal inflammation is 9 times that of curcumin (Science Advances 2025.02).

Policy trends 

• US DSHEA amendment: synthetic nicotine and epigenetic regulators are to be included in the mandatory NDI declaration scope (to be implemented in 2026)

• China Customs new regulations: imported probiotic raw materials must provide strain-level whole genome sequencing reports (to be implemented in July 2025)

Data sources for this article
 ✓ WHO "2025 Global Dietary Supplement White Paper"

✓ European Commission ETP Certification Database

✓ Innova Market Insights 2025Q1 Report

If you need customized regional market analysis (such as Southeast Asia Halal Ingredient Compliance Guide), or obtain the COA/stability report template for the raw materials mentioned in this article, please contact our technical team.

In 2025, China's health care product raw material industry will usher in policy and technology dual-wheel drive

1. Policy supervision is becoming stricter and industry standardization is accelerating

In 2025, China's health care product raw material industry will usher in a new round of policy adjustments. The Henan Provincial Market Supervision Bureau recently launched the "People's Inspection Day" activity, focusing on combating illegal additives, implementing a "weekly sampling and monthly reporting" system for campus food and online celebrity health products, and promoting the popularization of rapid testing technology. This move marks that food safety supervision across the country has entered a precise and normalized stage. Raw material manufacturers need to strengthen their compliance capabilities and focus on the updates of regulations such as the "Health Food Registration and Filing Management Measures" to adapt to the high standards of domestic and foreign markets for raw material traceability and safety.

2. Market size continues to expand, and the silver economy becomes the core driving force

According to Zhiyan Consulting data, the scale of China's health food industry will exceed 415.12 billion yuan in 2023, with a compound annual growth rate of 7.1%4. As the aging population exceeds 300 million (accounting for 21.1% of the total population)6, the demand for functional raw materials such as antioxidants and bone density improvement for middle-aged and elderly people has surged. At the same time, the young consumer group's focus on "precision nutrition" has driven the growth of the raw material market for innovative dosage forms (such as liposome encapsulation technology). In 2025, the global market size of raw materials related to liposome delivery technology is expected to increase by 35% year-on-year.

3. Technological innovation leads to raw material upgrade

Technology breakthroughs in the industry are concentrated in two major areas:

Improved bioavailability: Nanoliposomes and microencapsulation technologies have become research and development hotspots. For example, a company launched a targeted liposome glutathione raw material, which has a liver accumulation rate 5 times higher than that of traditional dosage forms and has been registered with the FDA dietary ingredient master file.

Sustainable production: Supercritical CO2 extraction and continuous production lines are popularized, and some companies have achieved a 52% reduction in unit production costs, while meeting the EU CSRD carbon footprint requirements.

4. Reshaping of the international trade pattern

The global health care product raw material supply chain presents new characteristics in 2025:

Improved export competitiveness: Chinese raw material companies, relying on cost advantages and technological iterations, occupy 30% of the global market share in the fields of plant extracts and probiotics, and Southeast Asia and the Middle East have become emerging export destinations.

Intensified compliance barriers: The European and American markets strengthen the review of "precision delivery" function claims, and the new EFSA regulations require raw material companies to provide cell-level experimental data such as transmembrane absorption rate.

5. The capital market is getting hotter

A-share market data on March 14 showed that the Food 50 Index rose by 6.60% in a single day, reflecting investors' increased confidence in the health food sector. Institutions predict that raw material suppliers with technological barriers will become the focus of capital attention, especially companies with patented delivery technology and international certification.

Industry Outlook In 2025, raw material companies need to focus on three strategic directions:

Compliance construction: Establish a full-chain digital management system from raw material traceability to production process;

Scenario-based innovation: Develop customized raw material solutions for oral beauty, sports nutrition and other segments;

ESG transformation: Use degradable packaging and green production processes to respond to global sustainable procurement trends

Brain health revolution! Global demand for Hericium erinaceus extracts soars, and the company launches highly active neuro-support raw material solutions ——In 2025, the functional food raw material market will usher in a new wave of "cognitive empowerment"

With the intensification of global aging and the explosive growth of consumers' demand for "brain power", Lion's Mane Extract has quickly become the focus of health care products and functional food raw materials in 2025 due to its unique neuroregeneration and cognitive enhancement effects. As a leading supplier of natural health ingredients in the world, joyouspellets Company officially launched high-purity standardized extract of Hericium erinaceus β-glucan, providing a full-link solution "from laboratory to shelf" for food, beverage and dietary supplement brands!

Scientific breakthrough: Hericium erinaceus extract becomes the "golden ingredient" in the brain health track

According to the "Nutrition Business Journal 2024 Annual Report", the global brain health raw material market is expected to exceed US$7.8 billion in 2025, with a compound annual growth rate of 29%. Among them, Hericium erinaceus extract has achieved market explosion due to two key studies:

In 2024, "Nature Neuroscience" confirmed that its core active ingredients Hericenones and Erinacines can promote the synthesis of nerve growth factor (NGF) and significantly improve memory and concentration;

In January 2025, the WHO White Paper on Healthy Aging listed it as a "Grade A recommended natural ingredient for delaying cognitive decline."

Consumers are no longer satisfied with basic immune support. They need "future products" that can cope with high-pressure life and improve brain performance.

Three core technical advantages of Hericium erinaceus extract of joyouspellets Company

Dual-effect activity standardization: β-glucan ≥ 40% + Hericenones ≥ 1.5%, using patented low-temperature two-phase extraction technology, the bioavailability is increased by 200% compared with traditional processes;

Full-chain traceability certification: the raw materials are derived from the Nordic sustainable forest planting base, passed ISO 16128 natural index certification, non-GMO and heavy metal zero residue detection;

Scenario application adaptation: providing water-soluble powder, nanoliposome encapsulation dosage form and customized flavor solutions, suitable for popular categories such as puzzle gummies, instant coffee, meal replacement powder, etc.

Global market trends in 2025: How will Hericium erinaceus subvert the industry?

The rise of workplace health track: Silicon Valley technology companies are the first to embed Hericium erinaceus ingredients into employee health plans, driving B2B2C product innovations such as "anti-fatigue energy bars" and "conference focus drinks";

New blue ocean of the silver economy: Japanese and European brands have launched "Hericium erinaceus + phosphatidylserine" compound capsules, focusing on the prevention of Alzheimer's disease function claims; 

Metacosmic health concept: American emerging brands combine brain wave monitoring equipment with Hericium erinaceus supplements, and enhance consumers' perception of efficacy through data visualization.

Media Contact:

[Contact Name]: Julie

[Position]: Project Mananger

Tel: +86-152-93122560 

Email:  Julie@joyouspellets.com 

Official Website: joyousbio.com

#brainhealth #hericiumerinaceusextract #anti-aging #functionalfood #sustainableingredients

China's foreign trade in health care raw materials in 2025: a global breakthrough driven by policy and innovation

Industry scale and growth momentum: Silver economy and technology empowerment dual engines

China's health care product raw material industry is ushering in a new round of growth cycle. According to iMedia Consulting data, the scale of China's health care product market will reach 328.2 billion yuan in 2023, and is expected to exceed 423.7 billion yuan in 2027, with an annual compound growth rate of more than 6%. The core driving force of this growth comes from policy support and upgrading of consumer demand: the State Council's "Opinions on Developing the Silver Economy and Promoting the Well-being of the Elderly" clearly proposed to encourage the development of health foods suitable for the elderly, and the improvement of health awareness of the "silver generation" and the "young generation" jointly promoted the expansion of the market. The global market is also vibrant. According to Nutrition Business Journal data, the scale of the global health food market reached US$156.2 billion in 2020, a year-on-year increase of 9.7%. As the world's second largest consumer market, China's output value exceeded 400 billion yuan in 2020. The revenue growth of leading companies such as Biostime Group confirms this trend.

Reshaping the export landscape: the rise of emerging markets and the resilience of traditional market

In 2023, China's exports of health care raw materials will reach US$540 million, a year-on-year increase of 42%, of which fish oil and cod liver oil products will contribute US$450 million, with a growth rate of 66%. In terms of imports, the scale of US$1.16 billion (year-on-year +10%) shows the continued demand for high-end raw materials in the domestic market. The export market structure has shown significant changes: Traditional markets: The United States is still the main destination for China's raw material exports, but its share has dropped from 45.27% in 2017 to 37.69% in 2023, indicating a decrease in dependence. Emerging markets: ASEAN, Latin America and other regions have outstanding growth rates. In 2023, exports to ASEAN will increase by 12.3%, Latin America will increase by 13.7%, and emerging economies such as Mexico and Saudi Arabia will have an annual compound growth rate of more than 13%. Southeast Asian countries such as Malaysia have deepened cooperation with China through agreements such as RCEP. In January 2025, China accounted for 10.8% of their exports, ranking third.

Future Outlook: Differentiated Competition and Sustainable Development

The industry will present three major trends:

Market stratification: The high-end market focuses on organic certification and patented ingredients, while the mid- and low-end markets explore emerging economies through cost-effectiveness. Technical barriers: Artificial intelligence detection and biosynthesis technology (such as fermentation to produce rare ingredients) may become the key to competition. ESG orientation: Low-carbon production processes (such as reducing packaging energy consumption) and sustainable raw materials (such as plant-based substitutes) will affect trade access.

Against the backdrop of global health awareness and supply chain restructuring, Chinese health care product raw material companies need to use policies as sails and technology as oars, seek new growth through functional innovation and market diversification, and continuously enhance their voice in the global value chain.

Extend life by 50%? MIT professor reveals: The anti-aging secret is hidden in the "Sirtuins family"?

Since its creation in 1901, the Nobel Prize has been an authoritative symbol in the global scientific field. This year’s award-winning research, especially major breakthroughs in aging, gene repair and regenerative medicine, makes people wonder: Will we be able to live longer and healthier lives in the future?

In 2000, the research group of MIT professor Leonard Guarente was surprised to find that the NAD+-dependent SIR2.1 protein could extend the lifespan of C. elegans by nearly 50%. A few years later, scientists discovered several proteins with similar functions, and since then the Sirtuins protein family has been created.

What is the Sirtuins protein family？

Sirtuins are a type of NAD+-dependent deacetylase that are widely distributed in cells; they are a large family of longevity proteins composed of a group of proteins, with a total of 7 subtypes, SIRT1~SIRT7. Sirtuins proteins play an important role in cellular stress resistance, energy metabolism, apoptosis and aging processes, so they are called longevity proteins. SIRT family members have different cellular localizations. Among them, SIRT1, SIRT6 and SIRT7 are mainly located in the nucleus; SIRT2 is mainly distributed in the cytoplasm, and some can be transferred to the nucleus to participate in cell cycle regulation; SIRT3, SIRT4 and SIRT5 are called mitochondrial Sirtuins and mainly exist in the mitochondrial matrix [2]

How Sirtuins Slow Aging？

1. DNA repair DNA damage is considered to be one of the basic causes of cellular aging. SIRT1, SIRT4 and SIRT6 are involved in DNA damage repair and play an important role in maintaining genome integrity. Therefore, they have become important anti-aging targets and delay aging mainly by promoting DNA repair and function.

2. Antioxidant Among Sirtuins, SIRT3 plays the most important role in antioxidant defense. The deacetylation of mitochondrial complexes by SIRT3 leads to an increase in electron transfer efficiency, thereby preventing the generation of ROS (reactive oxygen species) and delaying aging by inhibiting mitochondrial oxidative stress.

3. Control inflammation Senescent cells will change the cell microenvironment by secreting inflammatory mediators, inducing the senescence of neighboring cells and the expansion of tumor cells. SIRT1 can regulate inflammation and apoptosis through deacetylation of transcription factors to delay aging.

4. Activate longevity pathways. The longevity pathways currently discovered in the field of anti-aging research, such as AMPK, FOXO and other signaling pathways, can all be activated and promoted through Sirtuins. Moreover, Sirtuins also play an important role in maintaining telomere function, mitochondrial function and the self-renewal function of stem cells.

NAD+ is the only substrate that activates Sirtuins

NAD+ is an essential coenzyme for Sirtuins. Since Sirtuins spend most of their time in a dormant state, the presence of NAD+ is required to activate Sirtuins to perform functions, including metabolism, life extension, cellular stress response, etc. However, as we age, NAD+ levels decrease, leading to a decrease in the activity of Sirtuins, which affects the interaction between the nucleus and mitochondria, and affects cellular metabolism and antioxidant pathways. If the human body cannot produce enough NAD+ to meet these needs, the human body will gradually age and develop various diseases. Therefore, exogenous supplementation of NAD+ is crucial to maintaining NAD+ levels in the human body and delaying aging!

The role of NAD+ and Sirtuins in disease

1. Cardiovascular disease[6]

Studies have shown that for elderly people with heart failure, supplementing NAD+ can restore arterial Sirtuins activity, reduce age-related cardiac hypertrophy and myocardial remodeling, and extend healthy lifespan. This measure has a strong protective effect on ischemic myocardium and can be used for cardiac surgery or to reduce damage after myocardial infarction in elderly patients.

2. Chronic kidney disease[7]

Kidney damage and disease are common in older patients. Studies show that NAD+ levels are significantly reduced in conditions of acute kidney injury (AKI) and chronic kidney disease (CKD); there is growing evidence that NAD+ enhancement is beneficial in acute and chronic kidney injury. NAD+ can increase Sirt1 deacetylase activity and perform DNA repair, thereby regulating apoptosis, inflammation and fibrosis to protect the kidneys.

3. Neurodegenerative diseases[8]

Age is the greatest risk factor for neurodegenerative diseases, among which Alzheimer's disease (AD) is the most prevalent disease in the elderly. Studies have shown that AD is related to decreased levels of NAD+ and Sirtuins. Supplementing NAD+ can activate SIRT1 to inhibit oxidative stress and inflammatory signaling pathways in AD, thereby preventing the development of AD and playing a potential protective role [9].

Measures to delay aging

1. Supplement activators with some functional foods and nutritional supplements, which can activate SIRT1. For example, resveratrol, anthocyanins, etc. However, due to the nature of the drug, direct administration is not effective.

2. Moderate exercise research shows that mild physical activity is an effective activator of SIRT1. Moderate exercise can improve the quality of life and increase the body's resistance to oxidative stress.

3. Calorie restriction [10] Research shows that dietary caloric restriction (CR) is an effective method to extend lifespan and improve health. Through caloric restriction, increased levels of Sirtuins can be promoted, thereby delaying aging.

4. Supplementing NAD+ Usually oral nutrition, exercise and dietary restrictions cannot meet the body’s demand for NAD+. At this time, directly supplementing NAD+ is the most effective way to increase the level in the body.

Reference

[1] Ziętara P, Dziewięcka M, Augustyniak M. Why Is Longevity Still a Scientific Mystery? Sirtuins-Past, Present and Future. Int J Mol Sci. 202  2 Dec 31;24(1):728.

[2] Grabowska W, Sikora E, Bielak-Zmijewska A. Sirtuins, a promising target in slowing down the ageing process. Biogerontology. 2017 Aug;18(4):447-476.

[3] Wan W, Hua F, Fang P, et al. Regulation of Mitophagy by Sirtuin Family Proteins: A Vital Role in Aging and Age-Related Diseases. Front Aging Neurosci. 2022 May 9;14:845330.

[4] Moskalev A, Guvatova Z, Lopes I, et al. Targeting aging mechanisms: pharmacological perspectives. Trends Endocrinol Metab. 2022 Apr;33(4):266-280.

[5] Bonkowski MS, Sinclair DA. Slowing ageing by design: the rise of NAD and sirtuin-activating compounds. Nat Rev Mol Cell Biol. 2016 Nov;17(11):679-690. 

[6] Kane AE, Sinclair DA. Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases. Circ Res. 2018 Sep 14;123(7):868-885.

[7] Morevati M, Fang EF, Mace ML, et al. Roles of NAD+ in Acute and Chronic Kidney Diseases. Int J Mol Sci. 2022 Dec 21;24(1):137.

[8] Li F, Wu C, Wang G. Targeting NAD Metabolism for the Therapy of Age-Related Neurodegenerative Diseases. Neurosci Bull. 2024 Feb;40(2):218-240.

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Nature sub-journal: Scientists discover "natural anti-aging molecules" that extend average life span by 64%

What is the ceiling of human lifespan?

For a long time, biologists believed that there was a significant correlation between the "lifespan limit and the length of puberty", i.e. that the general lifespan of humans was approximately 10 times the length of puberty.Based on a 12-year puberty period, the life expectancy ceiling should be around 120 years, which is roughly the same as the value calculated by the American biologist Hevlik's limit.

However, in reality, the average life expectancy of human beings is far from being reached. According to the ranking of life expectancy per capita of countries in the world announced by the United Nations, China will rank 82nd in 2023 with an average life expectancy of 77.3 years, and even Japan, which ranks first, will have an average life expectancy of only 87.7 years.

 

How to slow down the aging process under genetic limitations has become a proposition that scientists around the world are struggling with.It is only in the last decade, with the rapid development of basic research, that a series of revolutionary breakthroughs have finally emerged in the field of aging intervention.

In July 2022, a study jointly released by the Chinese Academy of Sciences and the Ministry of Science and Technology of the People's Republic of China found that a substance called PCC1 (proanthocyanidin C1), when given to elderly subjects, showed strong senescent cell removal ability, but also extended the average life expectancy of the subjects by 64.2%, and the study is now published in the top medical journal "Nature Metabolism".The study was published in the top medical journal Nature Metabolism.

The researchers conducted an unbiased screening of a database of 46 plant species (the PDMA library).It was ultimately determined that a flavonoid, PCC1, found in a particular grape seed possessed an extremely strong potential to clear senescent cells.Compared to the classic DQ combination (quercetin + dasatinib) proposed by US scientists in 2019, PCC1 showed more targeted clearance and less cell-dependency in the experiment.

According to the Ealing 2024 interim report, the first half of Ealing achieved operating income of 4.606 billion yuan, of which the innovative anti-aging traditional Chinese medicine eight son capsule as one of the main research and development results, has received widespread attention.

Time: October 16-18, 2024

Address: Xi'an International Convention and Exhibition Center

With the support of the China Chemical and Pharmaceutical Industry Association, API China has become a brand event that collects industry characteristics, displays product technologies, helps companies interpret policies and regulations, improves industry production levels, and reflects industry development trends. The exhibition is supported by more than 97% of China's pharmaceutical industry companies and provides information exchange for pharmaceutical companies' decision-making, procurement, technology, and R&D personnel with target customers. The best opportunities for flow and business cooperation.

Exhibition description: As an exhibition representing new products and technologies in the pharmaceutical industry in China, with the full support of the China Chemical Pharmaceutical Industry Association and the China Pharmaceutical Packaging Association, API China & PHARMPACK & SINOPHEX & PHARMEX panoramically displays pharmaceutical raw materials, chemical intermediates, pharmaceutical packaging materials, pharmaceuticals The equipment industry chain focuses on improving the overall level of the pharmaceutical industry and creating a safety and health guarantee system with Chinese characteristics.

Each exhibition has more than 1,000 API companies, more than 300 pharmaceutical packaging companies, more than 200 pharmaceutical equipment companies, and 30,000 buyers from home and abroad gathered at the exhibition.

The three-day exhibition was a platform to find high-quality suppliers, explore technologies and processes, learn about new industry trends, and communicate and learn with colleagues in the industry.