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Miraculous AKG: a secret weapon to repair the reproductive system and protect the continuation of the race

1. What is AKG?

AKG, scientific name α-ketoglutarate, is an important metabolic substance present in the human body and is a key intermediate product in the tricarboxylic acid cycle (TCA cycle). It participates in a variety of biochemical reactions in the human body, especially playing a central role in energy metabolism, amino acid synthesis, and cell function maintenance. AKG is not only crucial in energy supply, but is also closely related to cell repair and regeneration. In recent years, studies have found that AKG has significant effects in anti-aging, improving immunity, and promoting tissue repair, so it is widely used in the fields of nutritional supplements and medical research.

2. AKG's repair and help for the reproductive system Promote sperm quality and motility

Due to factors such as high work pressure, lack of exercise, poor diet and other factors, modern men's sperm quality has generally declined, which has become one of the important causes of global fertility problems. Research has found that AKG can enhance sperm motility and quantity by improving cell mitochondrial function and increasing cell energy supply. In addition, AKG also has antioxidant effects, which can remove free radicals in the reproductive system, reduce oxidative damage to sperm, and significantly improve sperm quality.

Regulate hormone levels

The health of the reproductive system is closely related to hormone levels in the body. Ovarian function in women and testicular function in men are both regulated by hormone balance. AKG can balance the secretion of sex hormones in the body by regulating the function of the hypothalamic-pituitary-gonadal axis.

Enhance ovarian reserve function

A woman's ovarian reserve function is an important factor in determining fertility. As age increases, ovarian function gradually declines, the number and quality of follicles decrease, and fertility decreases significantly. AKG promotes the metabolism and repair of ovarian cells, delays ovarian aging, and improves follicle quality, thereby extending a woman's fertility window.

Improve the uterine environment

For women, the health of the lining of the uterus is crucial. The thickness and blood flow supply of the endometrium directly affect embryo implantation and pregnancy success rate. AKG can improve blood circulation, increase endometrial blood flow, optimize the uterine environment, and provide better conditions for embryo implantation. In addition, the anti-inflammatory effect of AKG can effectively reduce endometrial inflammation and improve pregnancy rates.

3. The mechanism of action of AKG Antioxidant effect

Cells within the reproductive system are highly susceptible to damage from oxidative stress. As a powerful antioxidant, AKG can effectively neutralize free radicals and reduce cell damage, thereby protecting the health of the reproductive system. 

Improve energy metabolism

AKG plays an important role in the tricarboxylic acid cycle, which can improve the energy metabolism efficiency of cells and provide sufficient energy support for reproductive cells. This is essential for the production and maturation of sperm and eggs.

Promote collagen synthesis

AKG participates in the synthesis of collagen, helps repair and maintain the structure and function of reproductive system tissues, and enhances the elasticity and health of reproductive organs.

4. Application prospects and suggestions of AKG Assisted Reproductive Treatment

In assisted reproductive technologies (such as in vitro fertilization and artificial insemination), AKG can be used as an auxiliary treatment to improve the success rate of fertility. Its ability to improve sperm and egg quality significantly increases the probability of conception.

Health products and daily supplements

For people with reproductive system problems or those who are planning to have children, appropriate supplementation of AKG can be used as a daily health care measure. Especially during the pregnancy preparation stage, AKG supplementation can help improve the fertility of both men and women.

Safety and usage precautions

At present, AKG has shown good safety in clinical studies, but it still needs to be used under the guidance of a doctor to avoid overdose. In addition, pregnant women, lactating women and people with serious diseases should use it rationally under the advice of professional doctors.

Revealed: Ten kinds of traditional Chinese medicine can help you grow in reverse and rejuvenate your body!

Do you feel helpless when facing the traces left by the years? Let's explore the anti-aging secrets of ten traditional Chinese medicines and regain your lost youth. Whenever we see those uninvited wrinkles in front of the mirror, or feel that our physical strength is no longer sufficient, we always lament the ruthlessness of time. 

 1. Ginseng – Improves wisdom

"Shen Nong's Materia Medica" records: "Ginseng nourishes the five internal organs, soothes the spirit, calms the soul, relieves panic, eliminates evil spirits, improves eyesight, makes people happy and improves intelligence. Long-term use can lighten the body and prolong life." Efficacy: Improve brain power, regulate the central nervous system, and eliminate fatigue. Recommended usage: Wash the whole ginseng or cut into slices, add water to soak for 30 minutes, simmer over slow fire for about 1 hour, and drink after the ginseng juice becomes warm. 

 2. Wolfberry - Guardian of the Liver

"Shen Nong's Materia Medica" records: "Long-term use will strengthen the bones and muscles, make the body light and not grow old, and can withstand cold and heat." Efficacy: Nourishes the liver and kidneys, replenishes essence and improves eyesight, enhances physical fitness, and delays aging. Recommended usage: Chew 2030 capsules in the morning and evening, or soak 3040 capsules in boiling water for drinking. 

 3. Astragalus – the source of cellular youth

"Shen Nong's Materia Medica" records: Astragalus is classified as top grade, which can replenish the body's qi and relieve qi deficiency and weakness and insufficient qi. Efficacy: Expand coronary arteries, improve blood supply to myocardium, improve immune function, and delay cell aging. Recommended usage: Use about 30 grams of astragalus every day, boil it in water before taking it, or add 15 grams of wolfberry, boil it in water and take it.

 4. Ganoderma lucidum - the nemesis of free radicals

"Shen Nong's Materia Medica" records: "Replenishing liver qi, calming the spirit and soul", "Eating for a long time can make you light up and not grow old, and prolong your life." Efficacy: Enhance coronary blood flow, reduce myocardial oxygen consumption, protect liver and detoxify, adjust immunity, relieve cough and asthma. Recommended usage: Ganoderma lucidum chicken soup: 20 grams of red mushroom, 20 grams of dried lily, 20 grams of dried lotus seeds, half a chicken, 3 slices of ginger, simmer over high heat for 1 hour.

5. Panax notoginseng—the patron saint of blood


"Compendium of Materia Medica" records: "Ginseng is the first to nourish qi, Panax notoginseng is the first to nourish blood, the taste is the same but the effects are equal." Efficacy: Anti-thrombosis, anti-cerebral ischemia, anti-myocardial damage, anti-arrhythmia, anti-inflammation, improve learning and memory. Recommended usage: Black-bone chicken stowed with Panax notoginseng and wolfberry: Black-bone chicken, ginger slices, Panax notoginseng, red dates, wolfberry, bring to a boil over high heat, then simmer over low heat for 50 minutes. 

 6. Polygonum multiflorum - antioxidant warrior

"Kaibao Materia Medica" of the Song Dynasty records: "Long-term use will strengthen bones and muscles, replenish the essence, and prolong life." Efficacy: Promote nerve cell growth, regulate cholesterol levels, and oxidation. Recommended usage: Fat control and longevity tea: Prepare Polygonum multiflorum and boil in water for 20 minutes, simmer with raw hawthorn, white chrysanthemum and green tea to make tea. 

 7. Rhodiola rosea – the nemesis of fatigue

"Qian Jin Yi Fang" records: "Sedum is non-toxic, lightens the body and improves eyesight, and long-term use can stimulate the spirit and prevent aging." Efficacy: Anti-hypoxia, anti-cold, anti-fatigue, anti-radiation, improve work efficiency, and delay body aging. Recommended usage: Fry rhodiola rosea in water to extract juice, thicken and season, and pour over steamed radish.

 8. Angelica – the harmonizer of blood

"Chinese Pharmacopoeia" records: Angelica sinensis has the functions of nourishing blood and activating blood circulation, regulating menstruation and relieving pain, and moistening intestines and laxative. Efficacy: Enriching blood and activating blood circulation, regulating menstruation and relieving pain, moistening intestines and laxative. 1 hour, season and eat.

9. Polygonatum – a supplement for vitality and energy

Traditional Chinese medicine records: Polygonatum odorifera has the effects of nourishing yin and moistening the lungs, tonifying the spleen and qi, and tonifying the kidneys and essence. Efficacy: Anti-fatigue, improve body immunity, delay aging. Recommended usage: 10g of polygonatum and 10g of wolfberry, decoction in water instead of tea. 

 10. Acanthopanax—a gas station for the spirit

Traditional Chinese medicine records: Acanthopanax has the functions of "tonifying qi and calming the nerves, replenishing the kidneys and strengthening the waist, activating blood circulation and unblocking collaterals". Efficacy: Brain strengthening, anti-fatigue, antioxidant, delaying aging, and improving immunity. Recommended usage: 10g of Acanthopanax and 6g of Schisandra chinensis, brew in boiling water, cover and let stand for more than 15 minutes.

AKG, PQQ, spermidine and ergothioneine: Comparing the four major anti-aging ingredients, who is the main anti-aging ingredient?



1. AKG (alpha-ketoglutarate): the core regulator of cell metabolism
Mechanism of action AKG is a key metabolic intermediate in the tricarboxylic acid cycle, generating energy (ATP) in mitochondria and supporting normal energy metabolism of cells. AKG slows down the aging process by mitochondria improving function and maintaining cell health and repair capabilities.
Advantages and Disadvantages Benefits: AKG works through multiple mechanisms, including improving mitochondrial function, reducing oxidative stress, anti-inflammatory, and enhancing immune function. This makes AKG show broad application prospects in extending lifespan and improving metabolic and immune health . encapsulation technologies such as liposomes.
Research prospects Multiple animal experiments have shown that AKG supplementation can extend lifespan and improve age-related aging indicators. It has high safety and broad application prospects in the overall anti-agi ng field , and is especially suitable as a daily anti-aging nutritional supplement.

2. PQQ (pyrroloquinoline quinone): an enabler of mitochondrial generation

1. Mechanism of action
PQQ is a potent antioxidant that promotes mitochondrial biogenesis, ie, stimulates the production of new mitochondria. Mitochondria are the energy factories of the cell. Healthy mitochondrial numbers and function are essential for maintaining cellular viability and slowing down aging.

2. Advantages and disadvantages Advantages: PQQ not only increases cellular energy production through mitochondrial biogenesis, but also acts as a potent antioxidant to reduce free radical damage. In addition, PQQ has a positive impact on brain function, cognitive health, and has great potential especially in the prevention of neurodegenerative diseases.

Cons: PQQ is less bioavailable and requires higher doses to significantly stimulate mitochondrial biogenesis. It is costly and expensive supplements are available on the market, and some populations are sceptical about its long-term effects.

3 Research prospects
PQQ's effects on boosting mitochondrial numbers and energy metabolism have been validated in several experiments, showing strong potential for improving cognitive function and supporting cardiovascular health in particular. However, its research in life extension is still in the early stages and more clinical trials are still needed.
III. Spermine: Activator of Autophagy
1. Mechanism of action
Spermidine is a naturally occurring polyamine molecule in the human body, and its most notable effect is the activation of autophagy. Autophagy is an important process for cells to remove damaging substances and wastes and to repair themselves. As we age, the ability of autophagy gradually declines, leading to deterioration of cellular health.
2. Advantages and disadvantages
Advantages: Spermidine extends cellular life by activating autophagy and helping cells to clean up damaged mitochondria, abnormal proteins and other wastes. It also regulates gene expression and supports the activity of longevity genes, demonstrating comprehensive support for the immune system, cardiovascular health, and cognitive function.
Weaknesses: intake of spermidine is dependent on the amount in the daily diet, its concentration in food is limited, and absorption and dose modulation of supplements remains a challenge. In addition, high-dose supplementation may trigger side effects, and the safety of current long-term administration still requires further research.

3. Research Prospects
Spermidine has demonstrated significant effects in studies on extending the lifespan of experimental animals, especially in cardiovascular and cognitive health. This makes spermidine a popular choice in anti-aging supplements, and it is expected to be further promoted through food fortification and supplements in the future.

Ergothioneine: a natural antioxidant and cytoprotective agent

1. Mechanism of action
Ergothioneine is a natural amino acid derivative with unique antioxidant ability that protects cells from free radical damage. It is particularly effective in protecting mitochondria and DNA, helping to maintain healthy cell function.

2. Advantages and Disadvantages
Advantages: Ergothioneine is not only a potent antioxidant, but also has unique anti-inflammatory properties that reduce age-related chronic inflammation. In addition, it has a protective effect on neurons, which is expected to delay the onset of neurodegenerative diseases.
Weaknesses: Ergothioneine is found in small amounts in everyday foods, mainly in certain mushrooms and grains, making it more difficult to consume adequate amounts from the diet. In addition, the market awareness of ergothioneine is low and its supplements are still in the early stages of development and promotion.

3. Research prospects
Studies have shown that ergothioneine has significant potential to slow cognitive decline and protect the cardiovascular and nervous systems. However, due to its scarcity in nature, further research is still needed on how to extract it on a large scale and apply it to human health.
V. Why AKG wins?
While PQQ, spermidine and ergothioneine have demonstrated strong roles in their respective anti-aging mechanisms, AKG stands out in the anti-aging field due to its versatility and broad adaptability. Here are the key reasons why AKG wins:

1. Multiple mechanisms of action
AKG not only supports mitochondrial function and improves cellular energy metabolism, but also helps the immune system stay young by reducing inflammation and oxidative stress. This multi-dimensional action makes AKG an all-encompassing anti-aging supplement, whereas other ingredients tend to be more prominent in one area.

2. Safety and longevity
As a naturally occurring metabolite in the body, AKG is relatively safe and not prone to side effects with long-term use. This gives AKG an advantage in long-term anti-aging management. While PQQ, spermidine and ergothioneine have shown superior anti-aging effects, their safety in long-term high-dose use still needs to be further verified.

3. Extensive research support
The anti-aging effects of AKG have been validated in several animal experiments, especially in extending healthy life span and immune system regulation. In contrast, although PQQ and spermidine also have good experimental data, their mechanism of action and prospects for wide application are still in the exploratory stage.
Conclusion: Four Ingredients Help Anti-Aging, AKG Leads the Way
On the path of anti-aging, AKG, PQQ, spermidine and ergothioneine each slow down aging and improve health through different pathways. However, AKG has gradually established its dominant position in the anti-aging field by virtue of its comprehensive role in metabolic regulation, immune support, anti-inflammatory and antioxidant effects. With further research, AKG is expected to become an important tool for extending healthy life and fighting aging.

References:

1. Alpha-Ketoglutarate: A Central Regulator of Metabolism and Aging - Cell Metabolism
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30356-7
2. PQQ and Mitochondrial Biogenesis: Enhancing Cellular Energy - Nature Reviews Molecular Cell Biology
https://www.nature.com/articles/nrm3207
3. Spermidine and Autophagy in Aging - Science Advances
https://www.science.org/doi/10.1126/sciadv.aau5335
4. Ergothioneine: The Mysterious Antioxidant - Journal of Nutritional Biochemistry
https://www.sciencedirect.com/science/article/pii/S0955286317300434

Prices of various vitamins surged in the third quarter! ! !

The "supply constraints of other manufacturers on the supply side" mentioned by NHU may refer to the explosion and fire at a chemical plant of BASF, the world's major vitamin supplier, in Ludwigshafen, Germany, at the end of July this year. Zhong Qi, senior analyst of the medical industry at Toubao Research Institute, told a reporter from Securities Daily: "BASF's Ludwigshafen factory is the main production base of vitamins in the world. Two production lines were affected by the force majeure of the fire and closed down, which directly caused The global supply of vitamins is tightening in the short term, causing price fluctuations in the market."

According to data provided by Shanghai Steel Federation, BASF's new and old vitamin A production lines have a total annual production capacity of 14,400 tons, accounting for approximately 27% of the global vitamin A production capacity.

Since vitamin A and vitamin E are mostly used in medicine, food, breeding and other industries, the supply and demand structure is relatively stable. Therefore, fluctuations in the supply end have relatively severe disturbances in back-end prices.

BASF recently released the latest developments in the Ludwigshafen incident. In the report, BASF stated that it expects to restart the production of vitamin A in early April next year and vitamin E in early July next year.

In addition, Chen Rong said that in the first three quarters of this year, except for vitamin A, vitamin E, vitamin D3, nicotinamide and other products that rose significantly, most of the others remained stable and fluctuated. How will the overall market of the vitamin industry develop in the future?

Chen Rong predicted that in the second half of this year, the overall tone of the vitamin industry will still be to consume inventory, and prices will remain stable. When low-priced supplies are exhausted early next year, it is expected that the prices of some varieties will usher in an upward trend.