Industry information

Brain health revolution! Global demand for Hericium erinaceus extracts soars, and the company launches highly active neuro-support raw material solutions ——In 2025, the functional food raw material market will usher in a new wave of "cognitive empowerment"

With the intensification of global aging and the explosive growth of consumers' demand for "brain power", Lion's Mane Extract has quickly become the focus of health care products and functional food raw materials in 2025 due to its unique neuroregeneration and cognitive enhancement effects. As a leading supplier of natural health ingredients in the world, joyouspellets Company officially launched high-purity standardized extract of Hericium erinaceus β-glucan, providing a full-link solution "from laboratory to shelf" for food, beverage and dietary supplement brands!

Scientific breakthrough: Hericium erinaceus extract becomes the "golden ingredient" in the brain health track

According to the "Nutrition Business Journal 2024 Annual Report", the global brain health raw material market is expected to exceed US$7.8 billion in 2025, with a compound annual growth rate of 29%. Among them, Hericium erinaceus extract has achieved market explosion due to two key studies:

In 2024, "Nature Neuroscience" confirmed that its core active ingredients Hericenones and Erinacines can promote the synthesis of nerve growth factor (NGF) and significantly improve memory and concentration;

In January 2025, the WHO White Paper on Healthy Aging listed it as a "Grade A recommended natural ingredient for delaying cognitive decline."

Consumers are no longer satisfied with basic immune support. They need "future products" that can cope with high-pressure life and improve brain performance.

Three core technical advantages of Hericium erinaceus extract of joyouspellets Company

Dual-effect activity standardization: β-glucan ≥ 40% + Hericenones ≥ 1.5%, using patented low-temperature two-phase extraction technology, the bioavailability is increased by 200% compared with traditional processes;

Full-chain traceability certification: the raw materials are derived from the Nordic sustainable forest planting base, passed ISO 16128 natural index certification, non-GMO and heavy metal zero residue detection;

Scenario application adaptation: providing water-soluble powder, nanoliposome encapsulation dosage form and customized flavor solutions, suitable for popular categories such as puzzle gummies, instant coffee, meal replacement powder, etc.

Global market trends in 2025: How will Hericium erinaceus subvert the industry?

The rise of workplace health track: Silicon Valley technology companies are the first to embed Hericium erinaceus ingredients into employee health plans, driving B2B2C product innovations such as "anti-fatigue energy bars" and "conference focus drinks";

New blue ocean of the silver economy: Japanese and European brands have launched "Hericium erinaceus + phosphatidylserine" compound capsules, focusing on the prevention of Alzheimer's disease function claims; 

Metacosmic health concept: American emerging brands combine brain wave monitoring equipment with Hericium erinaceus supplements, and enhance consumers' perception of efficacy through data visualization.

Media Contact:

[Contact Name]: Julie

[Position]: Project Mananger

Tel: +86-152-93122560 

Email:  Julie@joyouspellets.com 

Official Website: joyousbio.com

#brainhealth #hericiumerinaceusextract #anti-aging #functionalfood #sustainableingredients

China's foreign trade in health care raw materials in 2025: a global breakthrough driven by policy and innovation

Industry scale and growth momentum: Silver economy and technology empowerment dual engines

China's health care product raw material industry is ushering in a new round of growth cycle. According to iMedia Consulting data, the scale of China's health care product market will reach 328.2 billion yuan in 2023, and is expected to exceed 423.7 billion yuan in 2027, with an annual compound growth rate of more than 6%. The core driving force of this growth comes from policy support and upgrading of consumer demand: the State Council's "Opinions on Developing the Silver Economy and Promoting the Well-being of the Elderly" clearly proposed to encourage the development of health foods suitable for the elderly, and the improvement of health awareness of the "silver generation" and the "young generation" jointly promoted the expansion of the market. The global market is also vibrant. According to Nutrition Business Journal data, the scale of the global health food market reached US$156.2 billion in 2020, a year-on-year increase of 9.7%. As the world's second largest consumer market, China's output value exceeded 400 billion yuan in 2020. The revenue growth of leading companies such as Biostime Group confirms this trend.

Reshaping the export landscape: the rise of emerging markets and the resilience of traditional market

In 2023, China's exports of health care raw materials will reach US$540 million, a year-on-year increase of 42%, of which fish oil and cod liver oil products will contribute US$450 million, with a growth rate of 66%. In terms of imports, the scale of US$1.16 billion (year-on-year +10%) shows the continued demand for high-end raw materials in the domestic market. The export market structure has shown significant changes: Traditional markets: The United States is still the main destination for China's raw material exports, but its share has dropped from 45.27% in 2017 to 37.69% in 2023, indicating a decrease in dependence. Emerging markets: ASEAN, Latin America and other regions have outstanding growth rates. In 2023, exports to ASEAN will increase by 12.3%, Latin America will increase by 13.7%, and emerging economies such as Mexico and Saudi Arabia will have an annual compound growth rate of more than 13%. Southeast Asian countries such as Malaysia have deepened cooperation with China through agreements such as RCEP. In January 2025, China accounted for 10.8% of their exports, ranking third.

Future Outlook: Differentiated Competition and Sustainable Development

The industry will present three major trends:

Market stratification: The high-end market focuses on organic certification and patented ingredients, while the mid- and low-end markets explore emerging economies through cost-effectiveness. Technical barriers: Artificial intelligence detection and biosynthesis technology (such as fermentation to produce rare ingredients) may become the key to competition. ESG orientation: Low-carbon production processes (such as reducing packaging energy consumption) and sustainable raw materials (such as plant-based substitutes) will affect trade access.

Against the backdrop of global health awareness and supply chain restructuring, Chinese health care product raw material companies need to use policies as sails and technology as oars, seek new growth through functional innovation and market diversification, and continuously enhance their voice in the global value chain.

Extend life by 50%? MIT professor reveals: The anti-aging secret is hidden in the "Sirtuins family"?

Since its creation in 1901, the Nobel Prize has been an authoritative symbol in the global scientific field. This year’s award-winning research, especially major breakthroughs in aging, gene repair and regenerative medicine, makes people wonder: Will we be able to live longer and healthier lives in the future?

In 2000, the research group of MIT professor Leonard Guarente was surprised to find that the NAD+-dependent SIR2.1 protein could extend the lifespan of C. elegans by nearly 50%. A few years later, scientists discovered several proteins with similar functions, and since then the Sirtuins protein family has been created.

What is the Sirtuins protein family？

Sirtuins are a type of NAD+-dependent deacetylase that are widely distributed in cells; they are a large family of longevity proteins composed of a group of proteins, with a total of 7 subtypes, SIRT1~SIRT7. Sirtuins proteins play an important role in cellular stress resistance, energy metabolism, apoptosis and aging processes, so they are called longevity proteins. SIRT family members have different cellular localizations. Among them, SIRT1, SIRT6 and SIRT7 are mainly located in the nucleus; SIRT2 is mainly distributed in the cytoplasm, and some can be transferred to the nucleus to participate in cell cycle regulation; SIRT3, SIRT4 and SIRT5 are called mitochondrial Sirtuins and mainly exist in the mitochondrial matrix [2]

How Sirtuins Slow Aging？

1. DNA repair DNA damage is considered to be one of the basic causes of cellular aging. SIRT1, SIRT4 and SIRT6 are involved in DNA damage repair and play an important role in maintaining genome integrity. Therefore, they have become important anti-aging targets and delay aging mainly by promoting DNA repair and function.

2. Antioxidant Among Sirtuins, SIRT3 plays the most important role in antioxidant defense. The deacetylation of mitochondrial complexes by SIRT3 leads to an increase in electron transfer efficiency, thereby preventing the generation of ROS (reactive oxygen species) and delaying aging by inhibiting mitochondrial oxidative stress.

3. Control inflammation Senescent cells will change the cell microenvironment by secreting inflammatory mediators, inducing the senescence of neighboring cells and the expansion of tumor cells. SIRT1 can regulate inflammation and apoptosis through deacetylation of transcription factors to delay aging.

4. Activate longevity pathways. The longevity pathways currently discovered in the field of anti-aging research, such as AMPK, FOXO and other signaling pathways, can all be activated and promoted through Sirtuins. Moreover, Sirtuins also play an important role in maintaining telomere function, mitochondrial function and the self-renewal function of stem cells.

NAD+ is the only substrate that activates Sirtuins

NAD+ is an essential coenzyme for Sirtuins. Since Sirtuins spend most of their time in a dormant state, the presence of NAD+ is required to activate Sirtuins to perform functions, including metabolism, life extension, cellular stress response, etc. However, as we age, NAD+ levels decrease, leading to a decrease in the activity of Sirtuins, which affects the interaction between the nucleus and mitochondria, and affects cellular metabolism and antioxidant pathways. If the human body cannot produce enough NAD+ to meet these needs, the human body will gradually age and develop various diseases. Therefore, exogenous supplementation of NAD+ is crucial to maintaining NAD+ levels in the human body and delaying aging!

The role of NAD+ and Sirtuins in disease

1. Cardiovascular disease[6]

Studies have shown that for elderly people with heart failure, supplementing NAD+ can restore arterial Sirtuins activity, reduce age-related cardiac hypertrophy and myocardial remodeling, and extend healthy lifespan. This measure has a strong protective effect on ischemic myocardium and can be used for cardiac surgery or to reduce damage after myocardial infarction in elderly patients.

2. Chronic kidney disease[7]

Kidney damage and disease are common in older patients. Studies show that NAD+ levels are significantly reduced in conditions of acute kidney injury (AKI) and chronic kidney disease (CKD); there is growing evidence that NAD+ enhancement is beneficial in acute and chronic kidney injury. NAD+ can increase Sirt1 deacetylase activity and perform DNA repair, thereby regulating apoptosis, inflammation and fibrosis to protect the kidneys.

3. Neurodegenerative diseases[8]

Age is the greatest risk factor for neurodegenerative diseases, among which Alzheimer's disease (AD) is the most prevalent disease in the elderly. Studies have shown that AD is related to decreased levels of NAD+ and Sirtuins. Supplementing NAD+ can activate SIRT1 to inhibit oxidative stress and inflammatory signaling pathways in AD, thereby preventing the development of AD and playing a potential protective role [9].

Measures to delay aging

1. Supplement activators with some functional foods and nutritional supplements, which can activate SIRT1. For example, resveratrol, anthocyanins, etc. However, due to the nature of the drug, direct administration is not effective.

2. Moderate exercise research shows that mild physical activity is an effective activator of SIRT1. Moderate exercise can improve the quality of life and increase the body's resistance to oxidative stress.

3. Calorie restriction [10] Research shows that dietary caloric restriction (CR) is an effective method to extend lifespan and improve health. Through caloric restriction, increased levels of Sirtuins can be promoted, thereby delaying aging.

4. Supplementing NAD+ Usually oral nutrition, exercise and dietary restrictions cannot meet the body’s demand for NAD+. At this time, directly supplementing NAD+ is the most effective way to increase the level in the body.

Reference

[1] Ziętara P, Dziewięcka M, Augustyniak M. Why Is Longevity Still a Scientific Mystery? Sirtuins-Past, Present and Future. Int J Mol Sci. 202  2 Dec 31;24(1):728.

[2] Grabowska W, Sikora E, Bielak-Zmijewska A. Sirtuins, a promising target in slowing down the ageing process. Biogerontology. 2017 Aug;18(4):447-476.

[3] Wan W, Hua F, Fang P, et al. Regulation of Mitophagy by Sirtuin Family Proteins: A Vital Role in Aging and Age-Related Diseases. Front Aging Neurosci. 2022 May 9;14:845330.

[4] Moskalev A, Guvatova Z, Lopes I, et al. Targeting aging mechanisms: pharmacological perspectives. Trends Endocrinol Metab. 2022 Apr;33(4):266-280.

[5] Bonkowski MS, Sinclair DA. Slowing ageing by design: the rise of NAD and sirtuin-activating compounds. Nat Rev Mol Cell Biol. 2016 Nov;17(11):679-690. 

[6] Kane AE, Sinclair DA. Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases. Circ Res. 2018 Sep 14;123(7):868-885.

[7] Morevati M, Fang EF, Mace ML, et al. Roles of NAD+ in Acute and Chronic Kidney Diseases. Int J Mol Sci. 2022 Dec 21;24(1):137.

[8] Li F, Wu C, Wang G. Targeting NAD Metabolism for the Therapy of Age-Related Neurodegenerative Diseases. Neurosci Bull. 2024 Feb;40(2):218-240.

[9] López-Otín C, Blasco M, Partridge L, et al. The hallmarks of aging. Cell. 2013 Jun 6;153(6):1194-217.

[10] Longo V, Antebi A, Bartke A, et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 2015 Aug;14(4):497-510. 

Nature sub-journal: Scientists discover "natural anti-aging molecules" that extend average life span by 64%

What is the ceiling of human lifespan?

For a long time, biologists believed that there was a significant correlation between the "lifespan limit and the length of puberty", i.e. that the general lifespan of humans was approximately 10 times the length of puberty.Based on a 12-year puberty period, the life expectancy ceiling should be around 120 years, which is roughly the same as the value calculated by the American biologist Hevlik's limit.

However, in reality, the average life expectancy of human beings is far from being reached. According to the ranking of life expectancy per capita of countries in the world announced by the United Nations, China will rank 82nd in 2023 with an average life expectancy of 77.3 years, and even Japan, which ranks first, will have an average life expectancy of only 87.7 years.

 

How to slow down the aging process under genetic limitations has become a proposition that scientists around the world are struggling with.It is only in the last decade, with the rapid development of basic research, that a series of revolutionary breakthroughs have finally emerged in the field of aging intervention.

In July 2022, a study jointly released by the Chinese Academy of Sciences and the Ministry of Science and Technology of the People's Republic of China found that a substance called PCC1 (proanthocyanidin C1), when given to elderly subjects, showed strong senescent cell removal ability, but also extended the average life expectancy of the subjects by 64.2%, and the study is now published in the top medical journal "Nature Metabolism".The study was published in the top medical journal Nature Metabolism.

The researchers conducted an unbiased screening of a database of 46 plant species (the PDMA library).It was ultimately determined that a flavonoid, PCC1, found in a particular grape seed possessed an extremely strong potential to clear senescent cells.Compared to the classic DQ combination (quercetin + dasatinib) proposed by US scientists in 2019, PCC1 showed more targeted clearance and less cell-dependency in the experiment.

According to the Ealing 2024 interim report, the first half of Ealing achieved operating income of 4.606 billion yuan, of which the innovative anti-aging traditional Chinese medicine eight son capsule as one of the main research and development results, has received widespread attention.

Time: October 16-18, 2024

Address: Xi'an International Convention and Exhibition Center

With the support of the China Chemical and Pharmaceutical Industry Association, API China has become a brand event that collects industry characteristics, displays product technologies, helps companies interpret policies and regulations, improves industry production levels, and reflects industry development trends. The exhibition is supported by more than 97% of China's pharmaceutical industry companies and provides information exchange for pharmaceutical companies' decision-making, procurement, technology, and R&D personnel with target customers. The best opportunities for flow and business cooperation.

Exhibition description: As an exhibition representing new products and technologies in the pharmaceutical industry in China, with the full support of the China Chemical Pharmaceutical Industry Association and the China Pharmaceutical Packaging Association, API China & PHARMPACK & SINOPHEX & PHARMEX panoramically displays pharmaceutical raw materials, chemical intermediates, pharmaceutical packaging materials, pharmaceuticals The equipment industry chain focuses on improving the overall level of the pharmaceutical industry and creating a safety and health guarantee system with Chinese characteristics.

Each exhibition has more than 1,000 API companies, more than 300 pharmaceutical packaging companies, more than 200 pharmaceutical equipment companies, and 30,000 buyers from home and abroad gathered at the exhibition.

The three-day exhibition was a platform to find high-quality suppliers, explore technologies and processes, learn about new industry trends, and communicate and learn with colleagues in the industry.